CAS No. 1629229-37-3
Batch:
Purity:99.64
Chemical Structure
Check the
Fezolinetant
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4-fluorophenyl)-[(8R)-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]methanone | |
|---|---|---|
| CAS Number | 1629229-37-3 | |
| Molecular Formula |
C₁₆H₁₅FN₆OS |
|
| Molecular Weight (MW) | 358.39 | |
| InChIKey | PPSNFPASKFYPMN-SECBINFHSA-N |
Fezolinetant (ESN-364) is a selective antagonist of the neurokinin 3 receptor (NK3R). By disrupting hypothalamic neurokinin B signaling through NK3R, it interrupts pulsatile luteinizing hormone (LH) secretion and reduces plasma gonadotropin levels. Downstream, this suppression moderates circulating ovarian hormone levels, inhibiting the preovulatory LH surge and suppressing follicular phase estradiol and luteal phase progesterone rises throughout the menstrual cycle. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 9 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.