CAS No. 574013-66-4

Batch: Purity:99.09
Check CoA
fexaramine Chemical Structure
Chemical Structure
Check the fexaramine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl (E)-3-[3-[cyclohexanecarbonyl-[[4-[4-(dimethylamino)phenyl]phenyl]methyl]amino]phenyl]prop-2-enoate
CAS Number 574013-66-4
Molecular Formula

C32H36N2O3
Molecular Weight (MW) 496.64
SMILES CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)C=CC(=O)OC)C(=O)C4CCCCC4
InChIKey VLQTUNDJHLEFEQ-KGENOOAVSA-N

Ordering Information

Biological Activity

Fexaramine is a potent and selective farnesoid X receptor (FXR) agonist with an EC50 ofand displays high selectivity over other nuclear receptors. Activation of FXR by fexaramine regulates bile acid, lipid, and glucose homeostasis through gene expression modulation, including the induction of enteric fibroblast growth factor 15/19 (FGF15/19). Consequently, fexaramine treatment alters metabolic signaling, improves insulin sensitivity, and reduces weight gain in preclinical models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (50.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.