CAS No. 2768426-49-7
Batch:
Purity:97.52
Chemical Structure
Check the
FDW028
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-[(benzylamino)methyl]-2-[(4-ethylphenyl)methylamino]-1H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one | |
|---|---|---|
| CAS Number | 2768426-49-7 | |
| Molecular Formula |
C22H24N6O |
|
| Molecular Weight (MW) | 388.47 | |
| InChIKey | PAWBAUIXKSTNNX-UHFFFAOYSA-N |
Biological Activity
FDW028 is a highly potent and selective small-molecule inhibitor of fucosyltransferase 8 (FUT8). By promoting cellular protein defucosylation, FDW028 successfully induces the selective lysosomal degradation of B7-H3 via the chaperone-mediated autophagy pathway. In addition, FDW028 effectively suppresses downstream AKT/mTOR pathway signaling, demonstrating strong overall anti-tumor activity and potent therapeutic efficacy against metastatic colorectal cancer progression. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
39 mg/mL
(100.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.