CAS No. 883973-99-7

Batch: Purity:99.65
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FBPase-1 inhibitor-1 Chemical Structure
Chemical Structure
Check the FBPase-1 inhibitor-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,5-dichloro-N-(5-chloro-1,3-benzoxazol-2-yl)benzenesulfonamide
CAS Number 883973-99-7
Molecular Formula

C13H7Cl3N2O3S
Molecular Weight (MW) 377.63
SMILES ClC1=CC=C2OC(=NC2=C1)N[S;v6](=O)(=O)C3=C(Cl)C=CC(=C3)Cl
InChIKey JCXZHFCBNFFHRC-UHFFFAOYSA-N

Biological Activity

FBPase-1 inhibitor-1 is a benzoxazole benzenesulfonamide compound functioning as an allosteric inhibitor of fructose-1,6-bisphosphatase (FBPase-1). By binding to a unique allosteric site on FBPase-1, it suppresses enzymatic activity to regulate carbohydrate metabolism. Inhibition of FBPase-1 blocks the rate-limiting step of gluconeogenesis, leading to decreased endogenous glucose production and downstream attenuation of hepatic glucose output. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (264.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] von Geldern TW, et al. Bioorg Med Chem Lett. 2006;16(7):1811-5.

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Note: Technical data last updated: Sep 1, 2026.