CAS No. 125256-00-0
| IUPAC Name | 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)-1,3-thiazole | |
|---|---|---|
| CAS Number | 125256-00-0 | |
| Molecular Formula |
C18H18N2S |
|
| Molecular Weight (MW) | 294.41 | |
| SMILES | CCCC1=CC(=CC=N1)C2=NC(=CS2)C3=CC=C(C)C=C3 | |
| InChIKey | ZROSUBKIGBSZCG-UHFFFAOYSA-N |
Fatostatin is a diarylthiazole derivative that acts as a specific inhibitor of sterol regulatory element-binding protein (SREBP) activation. By directly binding to SREBP cleavage-activating protein (SCAP), Fatostatin blocks the translocation of SREBPs from the endoplasmic reticulum to the Golgi apparatus. Inhibition of the SREBP signaling pathway disrupts lipid biosynthesis, leading to suppressed cell proliferation and enhanced apoptosis in cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
75 mg/mL
(254.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 75 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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