CAS No. 2374782-02-0
Batch:
Purity:99.46
Chemical Structure
Check the
FAPI-4
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-[4,7-bis(carboxymethyl)-10-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid | |
|---|---|---|
| CAS Number | 2374782-02-0 | |
| Molecular Formula |
C40H54F2N10O10 |
|
| Molecular Weight (MW) | 872.92 | |
| InChIKey | ICWDAESAANBIGG-LJAQVGFWSA-N |
Biological Activity
FAPI-4 is a potent inhibitor of fibroblast activation protein (FAP), a type II transmembrane serine protease expressed on cancer-associated fibroblasts in the tumor microenvironment. By selectively binding to FAP, FAPI-4 disrupts tumor-stroma interactions and modulates extracellular matrix remodeling within the tumor microenvironment. Targeted inhibition of FAP suppresses fibroblast-mediated pro-tumorigenic signaling pathways, inhibiting stromal cell activity and suppressing cancer cell proliferation and invasion. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(114.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.