CAS No. 1044040-56-3
Batch:
Purity:96.48
Chemical Structure
Check the
Famitinib (SHR1020)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[2-(diethylamino)ethyl]-2-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one | |
|---|---|---|
| CAS Number | 1044040-56-3 | |
| Molecular Formula |
C23H27FN4O2 |
|
| Molecular Weight (MW) | 410.49 | |
| InChIKey | GKEYKDOLBLYGRB-LGMDPLHJSA-N |
Famitinib (SHR1020) is an orally active multi-targeted receptor tyrosine kinase inhibitor that potently targets c-Kit, vascular endothelial growth factor receptor 2 (VEGFR-2), and platelet-derived growth factor receptor β (PDGFRβ). By blocking receptor tyrosine kinase signaling, famitinib suppresses cancer cell proliferation by inducing G2/M cell cycle arrest and triggering dose-dependent apoptosis. Furthermore, inhibition of these targeted receptor tyrosine kinases disrupts tumor angiogenesis and significantly suppresses tumor growth in human xenograft models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
8 mg/mL
(19.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.