CAS No. 102676-47-1

Batch: Purity:99.94
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Fadrozole (CGS16949A) Chemical Structure
Chemical Structure
Check the Fadrozole (CGS16949A) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile
CAS Number 102676-47-1
Molecular Formula

C14H13N3
Molecular Weight (MW) 223.27
SMILES C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N
InChIKey CLPFFLWZZBQMAO-UHFFFAOYSA-N

Ordering Information

Biological Activity

Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase that exhibits selectivity over other cytochrome P-450 enzymes. By targeting aromatase, the compound blocks the enzymatic conversion of androgens into estrogens, thereby inhibiting downstream estrogen biosynthesis. This targeted inhibition suppresses estrogen receptor-mediated signaling pathways, resulting in suppressed estrogen-dependent cell proliferation and decreased hormone-driven tumor growth in preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 45 mg/mL (201.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 45 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.