CAS No. 1070790-89-4

Batch: Purity:99.88
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Fadraciclib (CYC065) Chemical Structure
Chemical Structure
Check the Fadraciclib (CYC065) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3S)-3-[[6-[(4,6-dimethyl-3-pyridinyl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol
CAS Number 1070790-89-4
Molecular Formula

C21H31N7O
Molecular Weight (MW) 397.52
SMILES CCC(NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=C(C)C=C(C)N=C3)C(C)O
InChIKey DLPIYBKBHMZCJI-WBVHZDCISA-N

Ordering Information

Biological Activity

Fadraciclib (CYC065) is a cyclin-dependent kinase (CDK) inhibitor that targets CDK2 and CDK9. By inhibiting CDK2 and CDK9, it suppresses RNA polymerase II phosphorylation and downregulates key anti-apoptotic and oncogenic proteins, including MCL1 and cyclin E. These downstream signaling effects disrupt transcription and cell cycle progression, ultimately inducing apoptosis and suppressing proliferation in preclinical cancer cell models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 80 mg/mL (201.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 80 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.