CAS No. 184475-71-6

Batch: Purity:99.34
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FAAH-IN-2 Chemical Structure
Chemical Structure
Check the FAAH-IN-2 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-ol
CAS Number 184475-71-6
Molecular Formula

C15H11ClFN3O2
Molecular Weight (MW) 319.72
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)O
InChIKey JLVTVCRXFMLUIF-UHFFFAOYSA-N

Biological Activity

FAAH-IN-2 is a synthetic small-molecule inhibitor targeting fatty acid amide hydrolase (FAAH). By inhibiting FAAH, the compound prevents the degradation of endogenous fatty acid amides, primarily anandamide, thereby enhancing endocannabinoid signaling pathways. This accumulation of lipid messengers promotes downstream cannabinoid receptor activation, influencing pain modulation, inflammation, and central nervous system signaling pathways. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (125.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kathuria S, et al. Nat Med. 2003;9(1):76-81.

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Note: Technical data last updated: Sep 1, 2026.