CAS No. 945531-77-1
Batch:
Purity:99.72
Chemical Structure
Check the
Ezutromid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole | |
|---|---|---|
| CAS Number | 945531-77-1 | |
| Molecular Formula |
C19H15NO3S |
|
| Molecular Weight (MW) | 337.39 | |
| SMILES | CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3 | |
| InChIKey | KSGCNXAZROJSNW-UHFFFAOYSA-N |
Biological Activity
Ezutromid is an orally active benzoxazole utrophin modulator that increases utrophin transcription and protein expression to compensate for the absence of dystrophin in muscle tissue. Utrophin upregulation stabilizes the sarcolemma, reduces muscle damage, and preserves skeletal muscle structural integrity, serving as a therapeutic strategy for Duchenne muscular dystrophy. Additionally, Ezutromid inhibits CYP1A2 enzymatic activity in human liver microsomes.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
4 mg/mL
(11.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.