CAS No. 1628830-21-6

Batch: Purity:97.49
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EZM 2302 (GSK3359088) Chemical Structure
Chemical Structure
Check the EZM 2302 (GSK3359088) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name methyl 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl]-2,7-diazaspiro[3.5]nonane-7-carboxylate
CAS Number 1628830-21-6
Molecular Formula

C29H37ClN6O5

 
Molecular Weight (MW) 585.09
SMILES CC1=C(N=C(N=C1N2CC3(C2)CCN(CC3)C(=O)OC)C4=C(C=CC(=C4)OCC(CNC)O)Cl)C5=C(ON=C5C)C
InChIKey OWCOTUVKROVONT-HXUWFJFHSA-N

Biological Activity

EZM 2302 (GSK3359088) is a potent and selective inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1). By blocking CARM1 enzymatic activity, EZM 2302 decreases intracellular asymmetric dimethylarginine levels on CARM1 substrates, modulating chromatin remodeling and downstream gene expression. This selective target inhibition suppresses cell proliferation and promotes cell cycle arrest in CARM1-dependent cancer cell lines, including multiple myeloma models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (158.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 93 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.