CAS No. 1412453-70-3

Batch: Purity:98.77
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EVT801 Chemical Structure
Chemical Structure
Check the EVT801 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-1-ethyl-7-[(3R)-3-hydroxy-4-methoxy-3-methylbut-1-ynyl]-3-(1H-imidazol-2-yl)-1,8-naphthyridin-4-one
CAS Number 1412453-70-3
Molecular Formula

C19H21N5O3
Molecular Weight (MW) 367.40
InChIKey FQPLKTQWEHDNAB-LJQANCHMSA-N

Biological Activity

EVT801 is a potent and selective inhibitor of vascular endothelial growth factor receptor 3 (VEGFR-3). By targeted inhibition of VEGFR-3 receptor tyrosine kinase activity, EVT801 attenuates downstream lymphangiogenic signaling cascades. This target engagement disrupts tumor-associated lymphangiogenesis, resulting in potent antitumor effects and suppressed vascular network expansion across VEGFR-3-expressing cellular and preclinical tumor models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (97.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.