CAS No. 6989-38-4
Chemical Structure
Check the
Evodine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy-3-methylbut-3-en-2-ol | |
|---|---|---|
| CAS Number | 6989-38-4 | |
| Molecular Formula |
C18H19NO5 |
|
| Molecular Weight (MW) | 329.35 | |
| SMILES | CC(=C)C(COC1=C(C2=C(C=C1)C(=C3C=COC3=N2)OC)OC)O | |
| InChIKey | LNJTUUHDKCPQAA-UHFFFAOYSA-N |
Biological Activity
Evodine is a natural product extracted from Evodiae fructus that functions as a potent inhibitor of P-glycoprotein (P-gp/ABCB1). By inhibiting P-gp-mediated efflux transport, Evodine blocks the active transport of xenobiotics across plasma membranes. This action leads to increased intracellular accumulation of substrate compounds, thereby attenuating ABC transporter-mediated drug resistance mechanisms in cellular models. [1]
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Note: Technical data last updated: Sep 1, 2026.