Eucalyptol

Synonyms: NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole

Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Eucalyptol Chemical Structure

Eucalyptol Chemical Structure

CAS: 470-82-6

Purity & Quality Control

Batch: Purity: 99.68%
99.68

Eucalyptol Related Products

Choose Selective Immunology & Inflammation related Inhibitors

Biological Activity

Description Eucalyptol (NSC 6171, 1,8-Cineol, 1,8-cineole, 1,8-Epoxy-p-menthane, 1,8-Oxido-p-menthane, Cineol, Cineole) is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects. Eucalyptol controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
In vitro
In vitro

In a concentration-dependent manner, 1,8-Cineol (Eucalyptol) reduces LPS-induced Egr-1 expression in nuclei and in whole cell of THP-1 cells, but shows no effect on NF-κB expression. 1,8-Cineol significantly inhibits cytokine production in human unselected lymphocytes of TNF-α, IL-1β, IL-4, IL-5, and in lipopolysaccharide (LPS)-stimulated monocytes of TNF-α, IL-1β, IL-6, and IL-8[1]. 1,8-Cineol significantly stimulates the transactivation of liver X receptor modulator LXR-α and LXR-β. The mRNA and protein expression of LXRs and their target genes, including ABCA1 and ABCG1, are significantly increased in macrophages stimulated with cineole. This leads to the subsequent removal of cholesterol from the cells[2].

Cell Research Cell lines THP-1 cells
Concentrations 1, 10, and 100 mg/L
Incubation Time 30 min
Method

The THP-1 cells are incubated with serial doses of 1,8-cineol (1, 10, and 100 mg/L, 30 min) before being stimulated with LPS (1 mg/L, 30 min). The localization of Egr-1 in the THP-1 cells is detected by immunofluorescence and a laser scanning confocal microscope. The expression of Egr-1 in the nuclei and whole cell, and NF-κB in the nuclei, are measured by Western blot analysis.

In Vivo
In vivo

In rats, it depresses myocardial contractility in a concentration-dependent way while increasing extracellular Ca2+ concentration. i.v. treatment of both anesthetized and conscious rats with 1,8-cineole lowers blood pressure, probably through an active vascular relaxation rather than withdrawal of sympathetic tone. 1,8-Cineole is also found to relax rat and guinea-pig (nonsensitized and ovalbumin-sensitized) airway smooth muscle by a nonspecific mechanism[2].

Animal Research Animal Models Male Swiss mice, Wistar rats
Dosages 100-400 mg/kg
Administration oral
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05559307 Recruiting
Ischemic Stroke Acute
Ying Gao|Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital|Dongzhimen Hospital Beijing
August 16 2022 Phase 4

Chemical Information & Solubility

Molecular Weight 154.25 Formula

C10H18O

CAS No. 470-82-6 SDF Download Eucalyptol SDF
Density 0.926 g/mL
Storage (From the date of receipt) 2 years -20°C liquid

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