CAS No. 269055-15-4

Batch: Purity:99.97
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Etravirine Chemical Structure
Chemical Structure
Check the Etravirine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-3,5-dimethylbenzonitrile
CAS Number 269055-15-4
Molecular Formula

C20H15BrN6O
Molecular Weight (MW) 435.28
SMILES CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N
InChIKey PYGWGZALEOIKDF-UHFFFAOYSA-N

Ordering Information

Biological Activity

Etravirine (TMC125) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV-1 reverse transcriptase. It binds directly to a hydrophobic pocket within the enzyme, effectively inhibiting RNA-dependent DNA polymerase activity and disrupting early viral cDNA synthesis. Consequently, etravirine suppresses retroviral replication and prevents the infection and destruction of host immune cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (199.87 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.