Etoposide is a potent Topoisomerase II poison. It affects p53, DDR, and ATM-Chk2 signaling by stabilizing the Topo II-DNA cleavage complex to accumulate DNA double-strand breaks, effectively inducing G2/M cell cycle arrest and apoptosis.
Etoposide IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for Etoposide Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.