CAS No. 24393-56-4

Batch: Purity:99.41
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Ethyl 4-Methoxycinnamate Chemical Structure
Chemical Structure
Check the Ethyl 4-Methoxycinnamate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate
CAS Number 24393-56-4
Molecular Formula

C12H14O3
Molecular Weight (MW) 206.24
SMILES CCOC(=O)C=CC1=CC=C(C=C1)OC
InChIKey DHNGCHLFKUPGPX-RMKNXTFCSA-N

Ordering Information

Biological Activity

Ethyl 4-methoxycinnamate is a natural cinnamate ester derivative possessing anti-inflammatory, antiangiogenic, and analgesic properties. It downregulates pro-inflammatory cytokines, including TNF-α and IL-1β, by suppressing NF-κB signaling pathway activation. Consequently, this compound attenuates vascular endothelial growth factor-induced angiogenesis and reduces the release of inflammatory mediators, leading to inhibited cellular proliferation, migration, and nociceptive responses.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 41 mg/mL (198.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.