CAS No. 86-35-1
Batch:
Purity:99.75
Chemical Structure
Check the
Ethotoin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 86-35-1 | |
|---|---|---|
| Molecular Formula |
C11H12N2O2 |
|
| Molecular Weight (MW) | 204.23 | |
| SMILES | CCN1C(=O)NC(C1=O)C2=CC=CC=C2 |
Biological Activity
Ethotoin is an orally active hydantoin derivative that acts as an anticonvulsant agent targeting neuronal voltage-gated sodium channels. By stabilizing the inactivated state of these channels, it inhibits high-frequency repetitive neuronal firing and limits seizure propagation in the central nervous system. These neuroprotective and antiepileptic properties make Ethotoin a valuable compound for studying neuronal excitability and epilepsy mechanisms. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(200.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.