Etelcalcetide HCl

Synonyms:

Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.

Etelcalcetide HCl Chemical Structure

Etelcalcetide HCl Chemical Structure

CAS: 1334237-71-6

Purity & Quality Control

Batch: P111001 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 99.78%
99.78

Etelcalcetide HCl Related Products

Signaling Pathway

Choose Selective CaSR Inhibitors

Biological Activity

Description Etelcalcetide HCl (AMG 416) is a novel synthetic peptide agonist of the calcium-sensing receptor (CaSR) composed of a linear chain of seven d-amino acids with a d-cysteine linked to an l-cysteine via a disulfide bond.
Targets
CaSR [1]

Chemical Information & Solubility

Molecular Weight 1084.71 Formula

C38H74ClN21O10S2

CAS No. 1334237-71-6 SDF --
Density 95.0~105.0%
Smiles Cl.CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(C)NC(=O)C(CC(S)C(N)(S)C(O)=O)NC(C)=O)C(=O)NC(CCCN=C(N)N)C(N)=O
Storage (From the date of receipt) 3 years-20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (92.19 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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