CAS No. 438-67-5

Batch: Purity:99.22
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Estrone sulfate sodium Chemical Structure
Chemical Structure
Check the Estrone sulfate sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name sodium [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfate
CAS Number 438-67-5
Molecular Formula

C18H22O5S.Na
Molecular Weight (MW) 373.42
InChIKey VUCAHVBMSFIGAI-ZFINNJDLSA-M

Ordering Information

Biological Activity

Estrone sulfate sodium is an endogenous estrogen conjugate that serves as a major circulating reservoir for active estrogens. It undergoes desulfation by steroid sulfatase (STS) to yield estrone, which can be further converted into 17β-estradiol. This pathway stimulates estrogen receptor signaling to promote gene transcription and cellular proliferation, establishing estrone sulfate as a key biological substrate in hormone-dependent breast cancer research. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 74 mg/mL (198.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.