CAS No. 2998-57-4
Batch:
Purity:98.49
Chemical Structure
Check the
Estramustine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] N,N-bis(2-chloroethyl)carbamate | |
|---|---|---|
| CAS Number | 2998-57-4 | |
| Molecular Formula |
C23H31Cl2NO3 |
|
| Molecular Weight (MW) | 440.40 | |
| InChIKey | FRPJXPJMRWBBIH-RBRWEJTLSA-N |
Biological Activity
Estramustine is an anti-mitotic and anti-microtubule agent that targets microtubule-associated proteins, including MAP1 and MAP2, to disrupt microtubule dynamics. By inhibiting the binding of MAP1 and MAP2 to taxol-stabilized microtubules and promoting MAP2-associated microtubule disassembly, it hinders proper microtubule assembly. Consequently, this disruption impairs mitotic spindle function and leads to cell cycle arrest during mitosis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 88 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.