CAS No. 119141-88-7
Batch:
Purity:98.17
Chemical Structure
Check the
Esomeprazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 6-methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1H-benzimidazole | |
|---|---|---|
| CAS Number | 119141-88-7 | |
| Molecular Formula |
C17H19N3O3S |
|
| Molecular Weight (MW) | 345.42 | |
| InChIKey | SUBDBMMJDZJVOS-DEOSSOPVSA-N |
Biological Activity
Esomeprazole is a potent inhibitor of the gastric proton pump, specifically targeting the H+,K+-ATPase enzyme in gastric parietal cells. By covalently binding to cysteine residues on the extracellular surface of the catalytic alpha subunit of H+,K+-ATPase, it suppresses the final step of gastric acid secretion. This inhibition elevates intragastric pH, suppressing baseline and stimulated gastric acid output to modulate acid-dependent gastrointestinal physiology. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 14 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.