CAS No. 65497-07-6

Batch: Purity:99.80
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Esculentoside A Chemical Structure
Chemical Structure
Check the Esculentoside A product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 65497-07-6
Molecular Formula

C42H66O16
Molecular Weight (MW) 826.96
SMILES COC(=O)C1(C)CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(OC6OCC(OC7OC(CO)C(O)C(O)C7O)C(O)C6O)C(C)(CO)C5CCC34C)C2C1)C(O)=O

Ordering Information

Biological Activity

Esculentoside A is a natural triterpenoid saponin with potent anti-inflammatory and immunosuppressive activities. It inhibits the NF-kB signaling pathway, suppressing the expression and secretion of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in lipopolysaccharide-stimulated macrophages. Through these actions, Esculentoside A attenuates inflammatory mediator release and cellular immune responses, demonstrating broad anti-inflammatory potential with low toxicity. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (120.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 2 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.