CAS No. 55854-43-8
Batch:
Purity:99.94
Chemical Structure
Check the
ES9-17
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-bromo-N-phenylthiophene-2-sulfonamide | |
|---|---|---|
| CAS Number | 55854-43-8 | |
| Molecular Formula |
C10H8BrNO2S2 |
|
| Molecular Weight (MW) | 318.21 | |
| InChIKey | AIZXCKZVUXCHAP-UHFFFAOYSA-N |
ES9-17 is a potent, selective, and reversible inhibitor of clathrin-mediated endocytosis (CME) that directly targets the N-terminal domain of the clathrin heavy chain. By binding to the clathrin heavy chain, ES9-17 disrupts clathrin-dependent vesicle formation and intracellular membrane trafficking. Consequently, this inhibition blocks the endocytic uptake of the lipophilic dye FM4-64 as well as multiple CME cargoes in Arabidopsis plants. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(201.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 64 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.