CAS No. 55224-05-0

Batch: Purity:97
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Erythromycin Cyclocarbonate Chemical Structure
Chemical Structure
Check the Erythromycin Cyclocarbonate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,2R,5R,6S,7S,8R,9R,11R,13R,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-hydroxy-6-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-3,15,17-trioxabicyclo[12.3.0]heptadecane-4,12,16-trione
CAS Number 55224-05-0
Molecular Formula

C38H65NO14
Molecular Weight (MW) 759.92
SMILES CCC1C2(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC3CC(C(C(O3)C)O)(C)OC)C)OC4C(C(CC(O4)C)N(C)C)O)(C)O)C)C)OC(=O)O2)C
InChIKey NKLGIWNNVDPGCA-ZDYKNUMJSA-N

Ordering Information

Biological Activity

Erythromycin Cyclocarbonate (Davercin) is a macrolide antibiotic derivative that acts as a bacterial protein synthesis inhibitor by targeting the 50S ribosomal subunit. By binding to the 50S subunit within the ribosomal nascent peptide exit tunnel, it blocks peptide chain elongation and disrupts bacterial translation. This inhibition halts essential protein production, leading to antibacterial activity against susceptible Gram-positive and select Gram-negative bacterial species. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (131.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.