CAS No. 1210344-57-2
Batch:
Purity:99.94
Chemical Structure
Check the
Ertugliflozin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1210344-57-2 | |
|---|---|---|
| Molecular Formula |
C22H25ClO7 |
|
| Molecular Weight (MW) | 436.88 | |
| SMILES | CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl |
Ertugliflozin (PF-04971729) is a potent and selective sodium-dependent glucose cotransporter 2 (h-SGLT2) inhibitor demonstrating over 1000-fold selectivity over h-SGLT1. By suppressing renal SGLT2 activity, Ertugliflozin blocks glucose reabsorption across the proximal renal tubules. This inhibition increases urinary glucose excretion, lowers plasma glucose concentrations, and improves metabolic homeostasis in diabetic animal models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | 10.8 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.