CAS No. 183321-74-6

Batch: Purity:99.99
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Erlotinib (CP-358774) Chemical Structure
Chemical Structure
Check the Erlotinib (CP-358774) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
CAS Number 183321-74-6
Molecular Formula

C22H23N3O4
Molecular Weight (MW) 393.44
SMILES COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC
InChIKey AAKJLRGGTJKAMG-UHFFFAOYSA-N

Ordering Information

Biological Activity

Erlotinib (CP-358774) is a potent EGFR inhibitor (IC50 = 2 nM) that exhibits greater than 1000-fold selectivity for EGFR over human c-Src and v-Abl. By inhibiting EGFR tyrosine kinase activity and autophosphorylation, erlotinib blocks downstream cell survival signaling pathways. This inhibition suppresses tumor cell proliferation and induces cell cycle arrest and autophagy in sensitive cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (254.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 11 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.