CAS No. 144143-96-4

Batch: Purity:99.99
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Eprosartan Mesylate Chemical Structure
Chemical Structure
Check the Eprosartan Mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 144143-96-4
Molecular Formula

C23H24N2O4S.CH4O3S
Molecular Weight (MW) 520.62
SMILES CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O.CS(=O)(=O)O

Ordering Information

Biological Activity

Eprosartan Mesylate (SKF-108566J) is a nonpeptide angiotensin II receptor antagonist that potently binds to the AT1 receptor (Kd ofin rat vascular smooth muscle cells). By blocking angiotensin II binding to AT1 receptors, it inhibits angiotensin II-mediated signaling pathways, preventing vasoconstriction and cellular proliferation. This selective inhibition disrupts downstream vascular smooth muscle contraction and suppresses hypertensive phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (192.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 17 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.