CAS No. 6873-09-2
Batch:
Purity:99
Chemical Structure
Check the
Epiberberine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 16,17-dimethoxy-5,7-dioxa-1-azoniapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),9,11,14,16,18-octaene | |
|---|---|---|
| CAS Number | 6873-09-2 | |
| Molecular Formula |
C20H18NO4 |
|
| Molecular Weight (MW) | 336.36 | |
| SMILES | COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC | |
| InChIKey | FPJQGFLUORYYPE-UHFFFAOYSA-N |
Epiberberine is a natural protoberberine alkaloid that acts as a potent urease inhibitor, targeting both Helicobacter pylori urease and jack bean urease. It suppresses adipocyte differentiation and cellular lipid accumulation by modulating the AKT and MAPK signaling pathways. Downstream, epiberberine downregulates adipogenic transcription factors, leading to reduced intracellular triglyceride levels and inhibited preadipocyte differentiation. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(199.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
12 mg/mL
(35.67 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.