CAS No. 2101938-42-3
Batch:
Purity:99.27
Chemical Structure
Check the
Enpatoran
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile | |
|---|---|---|
| CAS Number | 2101938-42-3 | |
| Molecular Formula |
C16H15F3N4 |
|
| Molecular Weight (MW) | 320.31 | |
| InChIKey | BJXYHBKEQFQVES-NWDGAFQWSA-N |
Enpatoran is a selective dual inhibitor of Toll-like receptor 7 (TLR7, IC50 = 11.1 nM) and Toll-like receptor 8 (TLR8, IC50 = 24.1 nM) in HEK293 cells. By blocking TLR7 and TLR8 activation by RNA-containing immune complexes, it suppresses downstream MyD88-dependent signaling and NF-kB activation. Consequently, it reduces the production of pro-inflammatory cytokines and type I interferons associated with autoimmune pathology.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.