CAS No. 2101945-93-9

Batch: Purity:99.44
Check CoA
Enpatoran Hydrochloride Chemical Structure
Chemical Structure
Check the Enpatoran Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile;hydrochloride
CAS Number 2101945-93-9
Molecular Formula

C16H15F3N4.ClH
Molecular Weight (MW) 356.77
InChIKey OHYZGHQWGHDMRP-ZVWHLABXSA-N

Ordering Information

Biological Activity

Enpatoran hydrochloride is a potent, orally active, dual Toll-like receptor 7 (TLR7) and Toll-like receptor 8 (TLR8) inhibitor. It targets single-stranded RNA sensing by suppressing TLR7/8 receptor activation, thereby blocking MyD88-mediated signaling pathways. Inhibition of this pathway impairs downstream NF-κB activation and interferon regulatory factor signaling, ultimately reducing the expression of proinflammatory cytokines and type I interferons involved in autoimmune inflammatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 18 mg/mL (50.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.