CAS No. 1256565-36-2

Batch: Purity:99.60
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Emvododstat (PTC299) Chemical Structure
Chemical Structure
Check the Emvododstat (PTC299) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
CAS Number 1256565-36-2
Molecular Formula

C25H20Cl2N2O3
Molecular Weight (MW) 467.34
SMILES COC1=CC=C(C=C1)C2N(CCC3=C2[NH]C4=C3C=C(Cl)C=C4)C(=O)OC5=CC=C(Cl)C=C5
InChIKey SRSHBZRURUNOSM-DEOSSOPVSA-N

Ordering Information

Biological Activity

Emvododstat (PTC299) is an inhibitor of vascular endothelial growth factor A (VEGFA) mRNA translation and dihydroorotate dehydrogenase (DHODH). By targeting DHODH, the rate-limiting enzyme in de novo pyrimidine nucleotide synthesis, it depletes cellular uridine nucleotides. This inhibition of pyrimidine biosynthesis suppresses VEGFA production, impairs inflammatory cytokine secretion, and inhibits cell proliferation, displaying potent activity in hematologic cancer models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (198.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.