Emetine hydrochloride

For research use only.

Catalog No.S3233 Synonyms: NSC 33669

Emetine hydrochloride Chemical Structure

CAS No. 14198-59-5

Emetine hydrochloride (NSC 33669), a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug, reduces HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α), PDK1, RhoA, Rho-kinases (ROCK1 and ROCK2) and BRD4. Emetine hydrochloride inhibits cellular autophagy and has anti-malarial, anti-viral, anti-bacterial and anti-amoebic effect.

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Biological Activity

Description Emetine hydrochloride (NSC 33669), a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug, reduces HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α), PDK1, RhoA, Rho-kinases (ROCK1 and ROCK2) and BRD4. Emetine hydrochloride inhibits cellular autophagy and has anti-malarial, anti-viral, anti-bacterial and anti-amoebic effect.
Targets
HIF-1α [1]
()
HIF-2α [1]
()
PDK1 [1]
()
RhoA [1]
()
ROCK1 [1]
()

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (193.38 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 517.1
Formula

C29H41ClN2O4

CAS No. 14198-59-5
Storage powder
in solvent
Synonyms NSC 33669

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HIF Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID