CAS No. 1181770-72-8
Batch:
Purity:99.94
Chemical Structure
Check the
EMD638683
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N'-[2-(3,5-difluorophenyl)-2-hydroxyacetyl]-2-ethyl-4-hydroxy-3-methylbenzohydrazide | |
|---|---|---|
| CAS Number | 1181770-72-8 | |
| Molecular Formula |
C18H18F2N2O4 |
|
| Molecular Weight (MW) | 364.34 | |
| SMILES | CCC1=C(C=CC(=C1C)O)C(=O)NNC(=O)C(C2=CC(=CC(=C2)F)F)O | |
| InChIKey | SSNAPUUWBPZGOY-UHFFFAOYSA-N |
EMD638683 is a selective inhibitor of serum- and glucocorticoid-inducible kinase 1 (SGK1). By blocking SGK1 activation, EMD638683 suppresses downstream epithelial sodium channel activity and attenuates renal sodium retention. This targeted pathway inhibition leads to decreased blood pressure and impairs tumor cell survival phenotypes, demonstrating its efficacy in cardiovascular and oncological disease models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 73 mg/mL |
| Water | Insoluble |
| DMSO |
73 mg/mL
(200.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 40 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.