CAS No. 226954-04-7
Batch:
Purity:99.86
Chemical Structure
Check the
Emapunil (AC-5216)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide | |
|---|---|---|
| CAS Number | 226954-04-7 | |
| Molecular Formula |
C23H23N5O2 |
|
| Molecular Weight (MW) | 401.46 | |
| SMILES | CCN(CC1=CC=CC=C1)C(=O)CN2C3=NC(=NC=C3N(C2=O)C)C4=CC=CC=C4 | |
| InChIKey | NBMBIEOUVBHEBM-UHFFFAOYSA-N |
Emapunil (AC-5216) is a selective translocator protein (TSPO/MBR) ligand that binds rat brain MBR (Ki 0.297 nM) and inhibits binding in rat glioma cells (IC50 3.04 nM) and human glioma cells (IC50 2.73 nM). By targeting mitochondrial TSPO, Emapunil enhances neurosteroid synthesis and GABAergic neurotransmission, producing pronounced anxiolytic-like and antidepressant-like effects in preclinical models without inducing sedative or motor side effects. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
80 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Emapunil (AC-5216) Clinical Trials
- Emapunil (AC-5216) Solubility in DMSO
- Emapunil (AC-5216) Stock Solution
- Emapunil (AC-5216) Storage
- Emapunil (AC-5216) Stability
- Emapunil (AC-5216) Molecular Weight
- Emapunil (AC-5216) SMILES
- Emapunil (AC-5216) Chemical Structure (2D and 3D)
- Emapunil (AC-5216) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.