CAS No. 1233948-35-0
Batch:
Purity:98.64
Chemical Structure
Check the
ELR-510444
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[5-(5-cyanothiophen-2-yl)-2-methylphenyl]-4-methylbenzenesulfonamide | |
|---|---|---|
| CAS Number | 1233948-35-0 | |
| Molecular Formula |
C19H16N2O2S2 |
|
| Molecular Weight (MW) | 368.47 | |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC2=C(C=CC(=C2)C3=CC=C(S3)C#N)C | |
| InChIKey | GRYXROIHHXHFND-UHFFFAOYSA-N |
ELR-510444 is a novel microtubule disruptor targeting cellular tubulin dynamics. By disrupting the microtubule network, it prevents proper spindle assembly and leads to the formation of aberrant mitotic spindles. This destabilization triggers mitotic arrest and promotes cell apoptosis in cancer cells, while also demonstrating antivascular activity that impairs tumor microvascular integrity. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(198.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.