CAS No. 119431-25-3
Batch:
Purity:99.80
Chemical Structure
Check the
Eliprodil (SL-820715)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 119431-25-3 | |
|---|---|---|
| Molecular Formula |
C20H23ClFNO |
|
| Molecular Weight (MW) | 347.85 | |
| SMILES | C1CN(CCC1CC2=CC=C(C=C2)F)CC(C3=CC=C(C=C3)Cl)O |
Eliprodil (SL-820715) is a non-competitive, NR2B subunit-selective NMDA receptor antagonist. By selectively binding to the polyamine domain of NR2B-containing NMDA receptors, it blocks glutamate-stimulated calcium ion influx into neuronal cells. Consequently, this targeted inhibition suppresses downstream excitotoxic signaling pathways, protecting cortical and hippocampal neurons against ischemia- and hypoxia-induced cell injury and death.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(57.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
| DMSO |
15 mg/mL
(43.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.