CAS No. 491833-29-5

Batch: Purity:99.8
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Eliglustat Chemical Structure
Chemical Structure
Check the Eliglustat product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]octanamide
CAS Number 491833-29-5
Molecular Formula

C23H36N2O4
Molecular Weight (MW) 404.54
SMILES CCCCCCCC(=O)NC(CN1CCCC1)C(C2=CC3=C(C=C2)OCCO3)O
InChIKey FJZZPCZKBUKGGU-AUSIDOKSSA-N

Biological Activity

Eliglustat (GENZ-112638) is a potent inhibitor of glucosylceramide synthase (GCS) that inhibits GCS with an IC50 ofin intact cells. By inhibiting GCS, Eliglustat blocks the rate-limiting step of glycosphingolipid biosynthesis, thereby lowering cellular glucosylceramide accumulation. This reduction in substrate influx lightens the lysosomal storage burden and restores glycosphingolipid homeostasis within cellular metabolic pathways. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 240 mg/mL (593.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 80 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] McEachern KA, et al. Mol Genet Metab. 2007;91(3):259-67.

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Note: Technical data last updated: Sep 1, 2026.