CAS No. 928659-70-5
Batch:
Purity:99.89
Chemical Structure
Check the
Eliglustat hemitartrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 928659-70-5 | |
|---|---|---|
| Molecular Formula |
C50H78N4O14 |
|
| Molecular Weight (MW) | 959.17 | |
| SMILES | CCCCCCCC(=O)NC(CN1CCCC1)C(O)C2=CC3=C(OCCO3)C=C2.CCCCCCCC(=O)NC(CN4CCCC4)C(O)C5=CC6=C(OCCO6)C=C5.OC(C(O)C(O)=O)C(O)=O |
Eliglustat hemitartrate is an orally active and specific inhibitor of glucosylceramide synthase with an IC50 of 24 nM. By inhibiting glucosylceramide synthase, it blocks the biosynthesis of glucosylceramide and decreases glycolipid substrate accumulation within lysosomes. This substrate reduction therapy lowers cellular glycosphingolipid burden and restores cellular metabolic homeostasis in preclinical models of lysosomal storage disorders. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(104.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 10 mg/mL |
| DMSO |
100 mg/mL
(104.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 50 mg/mL |
| DMSO |
100 mg/mL
(104.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Eliglustat hemitartrate Clinical Trials
- Eliglustat hemitartrate Solubility in DMSO
- Eliglustat hemitartrate Stock Solution
- Eliglustat hemitartrate Storage
- Eliglustat hemitartrate Stability
- Eliglustat hemitartrate Molecular Weight
- Eliglustat hemitartrate SMILES
- Eliglustat hemitartrate Chemical Structure (2D and 3D)
- Eliglustat hemitartrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.