CAS No. 1349723-93-8
| IUPAC Name | (6R)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;dihydrochloride | |
|---|---|---|
| CAS Number | 1349723-93-8 | |
| Molecular Formula |
C30H40Cl2N2O2 |
|
| Molecular Weight (MW) | 531.56 | |
| SMILES | CCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)C3CCC4=C(C3)C=CC(=C4)O | |
| InChIKey | XGFHYCAZOCBCRQ-FBHGDYMESA-N |
Elacestrant Dihydrochloride is an orally bioavailable selective estrogen receptor degrader (SERD) that targets ERα and ERβ. By binding to estrogen receptors, it promotes target receptor degradation and suppresses estrogen receptor-mediated transcriptional activity. This downregulation disrupts downstream signaling pathways required for cell survival and proliferation, leading to the inhibition of growth in ER-positive breast cancer models and suppression of xenograft tumor growth. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(188.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | 6 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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