CAS No. 1345839-28-2

Batch: Purity:98.214
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EIPA hydrochloride Chemical Structure
Chemical Structure
Check the EIPA hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1345839-28-2
Molecular Formula

C11H18ClN7O.ClH
Molecular Weight (MW) 336.22

Ordering Information

Biological Activity

EIPA hydrochloride is a small-molecule sodium-hydrogen exchanger (NHE) inhibitor that effectively blocks Na+/H+ exchange activity. Inhibition of Na+/H+ exchange by EIPA leads to submembranous intracellular acidification, which disrupts the recruitment and activation of small GTPases Rac1 and Cdc42 at the plasma membrane. This downstream signaling inhibition impairs actin cytoskeletal remodeling, suppresses membrane ruffling, and potently blocks macropinocytosis in mammalian cells. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 22 mg/mL (65.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.