CAS No. 10417-94-4

Batch: Purity:97.67
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Eicosapentaenoic Acid (EPA) Chemical Structure
Chemical Structure
Check the Eicosapentaenoic Acid (EPA) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
CAS Number 10417-94-4
Molecular Formula

C20H30O2
Molecular Weight (MW) 302.45
SMILES CCC=CCC=CCC=CCC=CCC=CCCCC(=O)O
InChIKey JAZBEHYOTPTENJ-JLNKQSITSA-N

Biological Activity

Eicosapentaenoic Acid (EPA) is an endogenous omega-3 polyunsaturated fatty acid with anti-inflammatory properties. EPA modulates inflammatory signaling by inhibiting NF-κB activation and suppressing pro-inflammatory cytokine production. Additionally, it serves as a substrate for lipid mediator synthesis and competes with arachidonic acid to attenuate cyclooxygenase-mediated eicosanoid formation, thereby dampening cellular inflammatory responses. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 60 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Calder PC. Biochim Biophys Acta. 2015;1851(4):469-84.

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Note: Technical data last updated: Sep 1, 2026.