CAS No. 861249-59-4
Batch:
Purity:99.70
Chemical Structure
Check the
Ehp-inhibitor-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(3-methoxyphenyl)-3-pyridin-3-ylpyrazolo[1,5-a]pyrimidin-7-amine | |
|---|---|---|
| CAS Number | 861249-59-4 | |
| Molecular Formula |
C18H15N5O |
|
| Molecular Weight (MW) | 317.34 | |
| SMILES | COC1=CC=CC(=C1)C2=C(N3C(=C(C=N3)C4=CN=CC=C4)N=C2)N | |
| InChIKey | KWGYGRTZRXWSAD-UHFFFAOYSA-N |
Ehp-inhibitor-1 is a small-molecule Eph family tyrosine kinase inhibitor that selectively targets Eph receptors. By inhibiting Eph receptor kinase activity, it blocks bidirectional ephrin signaling pathways and modulates downstream cell proliferation, migration, and survival mechanisms in tumor cells. Inhibiting these receptor tyrosine kinases impairs tumor angiogenesis and alters cell-matrix interactions involved in oncogenic signal transduction. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(126.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.