CAS No. 989-51-5
-Epigallocatechin-gallate-chemical-structure-S2250.gif)
| IUPAC Name | [(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate | |
|---|---|---|
| CAS Number | 989-51-5 | |
| Molecular Formula |
C22H18O11 |
|
| Molecular Weight (MW) | 458.37 | |
| InChIKey | WMBWREPUVVBILR-WIYYLYMNSA-N |
EGCG ((-)-Epigallocatechin Gallate) is a green tea-derived polyphenol flavonoid that inhibits telomerase and DNA methyltransferase (DNMT). EGCG blocks EGFR and HER2 receptor activation, while also inhibiting fatty acid synthase and glutamate dehydrogenase activities. Downstream, EGCG suppresses oncogenic signal transduction pathways, alters DNA methylation patterns, and induces apoptosis, demonstrating chemopreventive and antitumor activity across various cancer cell models. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(198.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 91 mg/mL |
| Ethanol | 91 mg/mL |
| DMSO |
92 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | 20 mg/mL |
| DMSO |
92 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 92 mg/mL |
| Ethanol | 92 mg/mL |
| DMSO |
92 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 92 mg/mL |
| Water | 20 mg/mL |
| DMSO |
92 mg/mL
(200.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | 20 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- EGCG ((-)-Epigallocatechin Gallate) Clinical Trials
- EGCG ((-)-Epigallocatechin Gallate) Solubility in DMSO
- EGCG ((-)-Epigallocatechin Gallate) Stock Solution
- EGCG ((-)-Epigallocatechin Gallate) Storage
- EGCG ((-)-Epigallocatechin Gallate) Stability
- EGCG ((-)-Epigallocatechin Gallate) Molecular Weight
- EGCG ((-)-Epigallocatechin Gallate) Chemical Structure (2D and 3D)
- EGCG ((-)-Epigallocatechin Gallate) SDS｜MSDS