CAS No. 1210945-69-9
Batch:
Purity:99.36
Chemical Structure
Check the
EG00229
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-[[3-(2,1,3-benzothiadiazol-4-ylsulfonylamino)thiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;2,2,2-trifluoroacetic acid | |
|---|---|---|
| CAS Number | 1210945-69-9 | |
| Molecular Formula |
C17H19N7O5S3.C2HF3O2 |
|
| Molecular Weight (MW) | 611.60 | |
| InChIKey | ZYQBITUOSRZDTG-MERQFXBCSA-N |
EG00229 is a neuropilin 1 (NRP1) receptor antagonist that inhibits VEGF-A binding to the NRP1 b1 domain with an ICof. By blocking VEGF-A interaction with NRP1, EG00229 attenuates VEGFR2 phosphorylation and inhibits downstream signaling, reducing endothelial cell migration. Additionally, EG00229 decreases carcinoma cell viability and sensitizes tumor cells to cytotoxic chemotherapeutics. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(163.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.