CAS No. 111011-63-3

Batch: Purity:99.05
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Efonidipine Chemical Structure
Chemical Structure
Check the Efonidipine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
CAS Number 111011-63-3
Molecular Formula

C34H38N3O7P
Molecular Weight (MW) 631.66
SMILES CC1=C(C(C(=C(N1)C)P2(=O)OCC(CO2)(C)C)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5
InChIKey NSVFSAJIGAJDMR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Efonidipine (NZ-105) is a dual L-type and T-type calcium channel blocker that regulates intracellular calcium influx. By inhibiting calcium entry through these channels, efonidipine promotes vasodilation and decreases cardiac automaticity. Additionally, it suppresses aldosterone secretion from adrenal cells, thereby contributing to the attenuation of renal and cardiovascular strain and modulating hemodynamics in vascular smooth muscle cells.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (158.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 6 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.