CAS No. 111011-76-8
Batch:
Purity:99.35
Chemical Structure
Check the
Efonidipine hydrochloride monoethanolate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(N-benzylanilino)ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate;hydrochloride | |
|---|---|---|
| CAS Number | 111011-76-8 | |
| Molecular Formula |
C36H45ClN3O8P |
|
| Molecular Weight (MW) | 714.18 | |
| SMILES | Cl.CCO.CC1=C(C(C2=CC(=CC=C2)[N+]([O-])=O)C(=C(C)N1)[P]3(=O)OCC(C)(C)CO3)C(=O)OCCN(CC4=CC=CC=C4)C5=CC=CC=C5 | |
| InChIKey | OXVTXPCIJDYQIS-UHFFFAOYSA-N |
Efonidipine hydrochloride monoethanolate is a dual L- and T-type calcium channel blocker that inhibits transmembrane calcium influx in vascular smooth muscle and cardiac cells. By blocking L-type and T-type calcium channels, it promotes vasodilation, reduces sinoatrial node automaticity, and decreases heart rate. Additionally, efonidipine suppresses aldosterone secretion from adrenal cortex cells, contributing to its antihypertensive and cardioprotective pharmacological profile. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(140.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Efonidipine hydrochloride monoethanolate Solubility in DMSO
- Efonidipine hydrochloride monoethanolate Stock Solution
- Efonidipine hydrochloride monoethanolate Storage
- Efonidipine hydrochloride monoethanolate Stability
- Efonidipine hydrochloride monoethanolate Molecular Weight
- Efonidipine hydrochloride monoethanolate SMILES
- Efonidipine hydrochloride monoethanolate Chemical Structure (2D and 3D)
- Efonidipine hydrochloride monoethanolate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.