CAS No. 164650-44-6
Batch:
Purity:99.97
Chemical Structure
Check the
Efinaconazole
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylidenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol | |
|---|---|---|
| CAS Number | 164650-44-6 | |
| Molecular Formula |
C18H22F2N4O |
|
| Molecular Weight (MW) | 348.39 | |
| SMILES | CC(C(CN1C=NC=N1)(C2=C(C=C(C=C2)F)F)O)N3CCC(=C)CC3 | |
| InChIKey | NFEZZTICAUWDHU-RDTXWAMCSA-N |
Efinaconazole (KP-103) is a triazole antifungal compound that acts as a potent inhibitor of fungal lanosterol 14α-demethylase (CYP51). By blocking 14α-demethylase activity, efinaconazole impairs ergosterol biosynthesis, leading to depletion of ergosterol and accumulation of toxic methylated sterol intermediates. This inhibition disrupts fungal cell membrane integrity and function, resulting in potent growth inhibition against a broad spectrum of pathogenic fungi, including dermatophytes and yeasts.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
69 mg/mL
(198.05 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 69 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.