CAS No. 154598-52-4
| CAS Number | 154598-52-4 | |
|---|---|---|
| Molecular Formula |
C14H9ClF3NO2 |
|
| Molecular Weight (MW) | 315.67 | |
| SMILES | C1CC1C#CC2(C3=C(C=CC(=C3)Cl)NC(=O)O2)C(F)(F)F |
Efavirenz is a non-nucleoside reverse transcriptase inhibitor that selectively targets human immunodeficiency virus type 1 reverse transcriptase. By binding to a hydrophobic pocket near the active site of the enzyme, it allosterically inhibits RNA-dependent DNA polymerase activity. This inhibition blocks the conversion of viral RNA into complementary DNA, effectively preventing viral genome replication and suppressing retroviral propagation in host cells. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
63 mg/mL
(199.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
| DMSO |
63 mg/mL
(199.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
| DMSO |
63 mg/mL
(199.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
| DMSO |
63 mg/mL
(199.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 63 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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